VHL and neoplasm: Then, we generated nineteen constructs of tumor-derived VHL mutants, including VHL S65L, V74D, N78S, S80R, P86L, W88L, L89H, Y98H, S111N, G114R, H115N, D121Y, L128H, V130L, I151T, L158P, C162F, R167W, and L178R.