Combined, SLC13A1 LoF variants associate with IDD in a LoF burden test (OR = 1.44, P = 3.1 × 10−11), with comparable effects observed in the three datasets holding individual level genotypes (ORIceland = 1.57, P = 8.6 × 10−4; ORUKB = 1.39, P = 1.9 × 10−3; ORDenmark = 1.43, P = 1.0 × 10−6) (Supplementary Data 13). Here, SLC13A1 is linked to intervertebral disk degenerative disorder.