Finally, we find other sources of evidence pointing to two additional back pain genes; GSDMC and COL11A1. In addition to the CHST3 locus, two other variants showed significant associations with both IDD and dorsalgia; the intergenic signals near GSDMC and the novel back pain variant downstream of COL11A1 (Table 1). This evidence concerns the gene CHST3 and intervertebral disk degenerative disorder.