The strongest association observed in this study is with a common variant in the 3′UTR region of CHST3, rs1871452-T (MAF = 39.1%) that associates with reduced risk of IDD (OR = 0.916, P = 1.57 × 10−39) and dorsalgia (OR = 0.962, P = 2.27 × 10−16). The gene discussed is CHST3; the disease is intervertebral disk degenerative disorder.