CHST3 and osteoarthritis: Several genes identified by our IDD and dorsalgia associations have also been implicated in inflammatory processes and consequential pain involved in the pathogenesis of osteoarthritis, such as the GSDMC, CHST3, SERPINA1, SPON2, SMAD3, TGFA, GDF5, COL11A1, and COL2A133,34.