Several genes identified by our IDD and dorsalgia associations have also been implicated in inflammatory processes and consequential pain involved in the pathogenesis of osteoarthritis, such as the GSDMC, CHST3, SERPINA1, SPON2, SMAD3, TGFA, GDF5, COL11A1, and COL2A133,34. This evidence concerns the gene SERPINA1 and osteoarthritis.