G6PD and melanoma: In A375 tumors, G6PD mutant cells had significantly lower levels of glutamate, succinate, fumarate, malate, and citrate (SI Appendix, Fig. S4A); however, in M214 and M481 melanomas, G6PD mutant tumors did not have lower levels of any TCA cycle intermediate as compared to control cells (SI Appendix, Fig. S4 B and C).