In COVID-19 patients, the studies reported elevated interleukins (IL) like IL-6, IL-8, IL-2R, IL-10, tumor necrosis factor (TNF-α), IL-1Ra, IP-10 (IFN-γ-induced protein 10) and macrophage inflammatory protein 1 (MCP-1) [17–21], especially in the severe group. This evidence concerns the gene TNF and COVID-19.