Here, our results provide an insight into lncRNA regulation by HDAC proteins and lead to a comprehensive understanding of LINC00461-associated networks in GBM malignancy, by expounding the utility of the HDAC6/RBPs/LINC00461 axis as a potential therapeutic approach for treating patients with GBM (Fig. 6E). The gene discussed is HDAC6; the disease is glioblastoma.