A highly conserved lncRNA, LINC00461, which functions as an essential regulator in glioma formation [13] and regulates the expressions of genes such as DNA topoisomerase II Alpha (TOP2A) [13], B-cell lymphoma 2 (BCL2) [14], and integrin β3 (ITGB3) [15], was identified to be remarkably downregulated by HDAC6 depletion. The gene discussed is TOP2A; the disease is central nervous system cancer.