Moreover, survival analysis using clinical outcome data showed that several cell-division-related genes (CENPF, DLGAP5, GTSE1, HMMR, KIF14, MCM10, MELK, RACGAP1, TMPO, and TOP2A) have poor prognostic implications in high-grade gliomas (Fig. 5F and Fig. S4A), suggesting that the reducing expressions of these genes through HDAC6/LINC00461 inhibition may improve outcomes in GBM patients. This evidence concerns the gene TOP2A and central nervous system cancer.