Considering the inhibitory potency of MPT0B291 on HDAC1 and 2 (IC50 ≈ 0.31 and 1.16 μM, respectively) [10, 11], the impact of HDAC1 and HDAC2 on LINC00461 expression was also examined in GBM cells using siRNA-mediated depletion. This evidence concerns the gene HDAC2 and glioblastoma.