Evidence gathered shows that MPT0B291 treatment significantly reduced subcutaneous tumor growth along with a decreased level of LINC00461 and a negative correlation between LINC00461 expression and survival of mice with intracerebral GBM, suggests a pivotal role for LINC00461 as an oncogenic factor in GBM malignancy. The gene discussed is MIR9-2HG; the disease is neoplasm.