To investigate the role of HDAC6 on these RNA-regulating proteins, HDAC6 inhibition was induced by MPT0B291 treatment or HDAC6 knockdown and this caused a significant decrease in FUS expression in both parental and TMZ-resistant GBM cells and a significant increase in CNOT6 expression (Fig. 3I–J and Fig. S3C). Here, CNOT6 is linked to glioblastoma.