An unanswered question remains whether this process involves a dedifferentiation step in which the adenocarcinoma cells first loose AR-specific gene expression and acquire basal or stem-like properties before proceeding to a second step in which they differentiate into NE cells, or whether the transdifferentiation arises directly skipping this putative intermediate stem-like cell stage [21, 22]. This evidence concerns the gene AR and adenocarcinoma.