UTS2R and glioblastoma: Chemotactic GPCRs, including the C-X-C chemokine receptor CXCR4 and the urotensin 2 receptor UTS2R, can prevent the formation of pre-autophagosomal and induce a marked reduction in the autophagosomes formation via the activation of calpains in both U87 glioblastoma and HEK-293 cells, which favors the formation of adhesion complexes to the extracellular matrix and promotes chemotactic migration [235].