The tumor-neuroglia interaction is activated by coculture of SCs with PanCa cells, in which interleukin 1β (IL1β) is secreted by tumor cells and then activates the nuclear actor (NF)-kappa B pathway in SCs, resulting in increased interleukin 6 (IL-6) and promoting cancer cell migration and invasion by activating STAT3 signaling in cancer cells [37]. Here, IL6 is linked to neoplasm.