Another confirmed receptor for MaR1 is retinoic acid-related orphan receptor α (RORα), which induces nonalcoholic steatohepatitis (NASH) protection through the MaR1/RORα/12-lipoxygenase (12-LOX) autoregulatory circuit [59]. Here, ALOX12 is linked to metabolic dysfunction-associated steatohepatitis.