SLC1A2 and GLUL transcripts, encoding for EAAT2 and GS, respectively, are downregulated in AD astrocytes in snRNA-seq studies [8–10, 12] (Fig. S3: Additional file 2); however, immunohistochemical [54] and biochemical [55] studies have yielded conflicting results. Here, SLC1A2 is linked to Alzheimer disease.