Apart from sepsis-induced neuroinflammation and the subsequent production in the brain of proconvulsive cytokines in the brain, such as TNFα and IL-1β, which may be involved in neuronal activity changes [7], the results of this study suggest that the dysregulation of the ion channel Kir4.1 of astrocytes plays an important role in the underlying mechanism for changes in seizure threshold in LPS-treated mice. This evidence concerns the gene TNF and Sepsis.