To the best of our knowledge, this study was the first report of the existence of autoantibodies against α-enolase and VDAC1 in serum from children with B-ALL by a proteomic approach, nevertheless, the α-enolase autoantibody was not all specific to B-ALL serum and were found in the serum of patients with other tumors, as well as α-enolase antibodies were found in some autoimmune diseases [33–35]. The gene discussed is VDAC1; the disease is autoimmune disease.