MUC16 and cancer: MUC gene mutation analysis showed that MUC16 (OMIM 606154) has the highest mutation frequency in G34-DHGs, followed by MUC17. A pan-cancer analysis involving somatic mutations of 10,195 samples and mRNA expression profiles of 9850 samples for 30 solid tumors found a greater abundance of immune cells in the microenvironment of MUC16-mutated tumors, and MUC16 mutation was associated with factors associated with response to immune checkpoint inhibitor therapy[14].