PDGFRA and central nervous system cancer: A high proportion of gliomas, especially TERTp wild-type GBM, are associated with somatic alterations in PDGFRA. Recurrent PDGFRA mutations have also been found in low-grade neurotumors associated with refractory seizures, called septal dysplasia neuroepithelial tumors or mucinous glial neuronal tumors [21].