The differentially expressed factors identified in all T2D groups compared to healthy controls were also associated with Cardiovascular System Development and Function, Cellular Development, Cellular Function, and Maintenance, with six focus molecules (Angiopoietin-2, Leptin, PF4, Serpin E1, Serpin F1, and THBS1) and a significance score of 18 (Fig. 6D). Here, LEP is linked to type 2 diabetes mellitus.