Serpin E1 was significantly reduced in patients with diabetes with ACS and CCAD (62.200 ± 41.4 and 50.900 ± 28.3, respectively) when compared with controls (92.200 ± 47.3, p < 0.05) but was not affected in patients without CAD (71.000 ± 29.5). The gene discussed is SERPINE1; the disease is coronary artery disorder.