These comparisons revealed that in all T2D groups, 6 factors were differentially expressed when compared to healthy controls, including Angiopoietin-2 (p = 0.018), Leptin (p = 0.038), PF4 (p = 0.001), Serpin E1 (p = 0.001), Serpin F1 (p = 0.027) and THBS1 (p = 0.001) (Fig. 5B). Here, ANGPT2 is linked to type 2 diabetes mellitus.