In contrast, in the PAC group (Fig. 4A), cell line Adcarc1258, its tumor tissue P1 and the tumor P2 were noticeable due to their relatively low expression of the epithelial cytokeratin genes, CDH1 and UPK3A. Additionally, Adcarc1258 showed a relatively high expression of the mesenchymal marker VIM in trend, while the other PAC cell lines and tissue P3 behaved in the opposite manner. The gene discussed is VIM; the disease is gonorrhea.