RBM3 and periampullary adenocarcinoma: Contrastingly, an inverse correlation has been denoted in pancreatic and other periampullary adenocarcinoma, where increased RBM3 protein levels were associated with more aggressive clinicopathological characteristics and a worse prognosis [18], as well as in hepatocellular carcinoma, where high RBM3 levels were shown to promote cellular proliferation, xenografted tumour growth, and signified an impaired survival [38].