Given that RBM3 expression was frequently denoted in the MIBC cohort (84.8% of patients) and the finding of a reduced risk of recurrence and a prolonged survival in NAC-treated patients with high RBM3 expression, we sought to elucidate mechanisms related to RBM3 function in MIBC using an in vitro model of the well-characterized human bladder cancer cell lines RT4 and T24, of which the latter represents invasive disease [35]. The gene discussed is RBM3; the disease is urinary bladder carcinoma.