evaluated the expression of VDR and ERp57/PDIA3 in different prostate cancer (PCa) cell lines (PNT2, P4E6, LNCaP, DU145, and PC3), representing different stages of tumor progression, and identified a novel transcript isoform of ERp57/PDIA3 (PDIA3N, an N-truncated isoform of ERp57/PDIA3; ENST00000538521.1, GRCh37.p13 Ensembl 2018). This evidence concerns the gene PDIA3 and Familial prostate cancer.