The role of ERp57/PDIA3 was linked to ER stress pathways [97], which characterize diseases such as Alzheimer’s disease (AD) [98] and amyotrophic lateral sclerosis (ALS) [99] (in this case, ERp57/PDIA3 also plays a role because of its interaction with the MAM compartment [100]). Here, PDIA3 is linked to amyotrophic lateral sclerosis.