SOX5 and Tolchin-Le Caignec syndrome: Moreover, given the fact that SOX5 and SOX6 heterozygous inactivating variants cause neurodevelopmental diseases in humans (Lamb-Shaffer and Tolchin-Le Caignec syndromes, respectively), our findings will also shed light on the neural alterations present in those SOXopathies (Angelozzi and Lefebvre, 2019).