There is more specific evidence of significant plasticity in the membrane contour of HER2-amplified cancer cells, including ruffles, folds, and protrusions such as filopodia, where HER2 is concentrated and across which intracellular kinase domains can interact without proximation of the ECDs (Chung et al., 2016; Hommelgaard et al., 2004). This evidence concerns the gene ERBB2 and cancer.