In addition, the whole-cell (including intracellular) localization of HER2-HER3 dimers seen in our SNAP complementation system replicates the observations from PLA and fluorescence resonance energy transfer (FRET)-based assays of HER2-HER3 dimers performed on formalin-fixed paraffin-embedded (FFPE) sections of HER2-amplified cancers (Barros et al., 2014; Fichter et al., 2014; Green et al., 2014; Kennedy et al., 2019; Weitsman et al., 2016). The gene discussed is ERBB2; the disease is cancer.