The results demonstrated that the levels of Ifnb1 transcripts in the liver and IFNβ in the blood in the Sting KO mice were much less than those in wild-type mice at both 4 and 7 weeks post infection (Fig 5E and 5F), indicating that STING is required for the induction of IFNβ during S. japonicum infection. This evidence concerns the gene STING1 and infection.