Activation of this signaling pathway plays an important role in the host response to infection by multiple types of pathogens, including viruses [51,52], bacteria including Mycobacterium tuberculosis [53], Listeria monocytogenes [54], and Neisseria gonorrhoeae [55], as well as parasites [22–27], which is largely dependent on STING. The gene discussed is STING1; the disease is infection.