We then observed the size of granulomas formed by individual eggs and the quantitative data showed that the sizes of granulomas of eggs in the liver of wild-type and Cgas-/- mice were 0.9205 ± 0.4383 mm2 and 0.4762 ± 0.3718 mm2, respectively (p = 0.0010) (Fig 1H and 1I), suggesting that cGAS promotes egg-induced granuloma formation during S. japonicum infection. Here, CGAS is linked to Granuloma.