LIPG and colorectal carcinoma: Here, through a comprehensive functional annotation for all the CRC susceptibility loci obtained from GWASs, followed by functional experiments, we observed that three plausible functional variants (rs77544449, rs60385309 and rs72917785), which were in high LD with the risk SNP rs7229639, had allele-specific effects on enhancer activity, thus possibly modulating the expression of LIPG.