Mutations in histone modifiers KMT2D (histone-lysine N-methyltransferase 2D) and KDM6A (lysine-specific demethylase 6A) (33) and EHMT1 (euchromatic histone-lysine N-methyltransferase 1) (34) have also been associated with syndromic congenital heart disease due to defects in NCC development (35). Here, SLC12A3 is linked to congenital heart disease.