We have previously reported that PD-L1 can be used as an important prognostic predictor in human esophageal cancer, and confirmed that PD-L1 can potentially contribute to the EMT of esophageal cancer cells by successfully establishing cellular models including PD-L1 knockdown expression and PD-L1 over-expression in Eca-109 cell line [6]. The gene discussed is CD274; the disease is esophageal cancer.