Moreover, it has been demonstrated that, PD-L1 transgenic-derived keratinocytes and squamous cell carcinoma cells exhibit a marked reduction of E-cadherin, and elevated expression of the transcription factors Slug and Twist, suggesting that the over-expression of PD-L1 in keratinocytes can promote EMT and accelerate carcinogenesis [5]. The gene discussed is CD274; the disease is squamous cell carcinoma.