CTNNB1 and Leber congenital amaurosis: More recently, a new LCA molecular classification was proposed based on themolecular profile in four different pathways: activation of β-catenin,interleukin 6/JAK/STAT, the sonic hedgehog pathway, and HNF1α inactivation.Based on these molecular features, a new subtype was identified (the sonichedgehog LCA [shLCA]), and the β-LCAs were divided into two further subgroupsaccording to the presence of CTNNB1 mutations (exon 3 vs. exons 7/8).