It is regulated in many types of cancer, such as glioblastomas,melanomas, breast cancer, and colon cancer, promoting invasion and metastasis.Inhibition of MMP2 has been shown to cause radiosensitization, a decrease in tumorgrowth, and invasiveness, identifying this enzyme as an interesting target for thedevelopment of diagnostic and therapeutic approaches.17 The gene discussed is MMP2; the disease is colonic neoplasm.