Besides, RBCK1 (RANBP2-type and C3HC4-type zinc finger-containing 1) has been shown to directly interact with p53 protein and facilitate its polyubiquitination and degradation, restoring the function of p53 by RBCK1, which is considered a promising strategy for renal cell carcinoma therapy (44). This evidence concerns the gene RBCK1 and hereditary clear cell renal cell carcinoma.