found the ApoE4 (a genetic risk factor for Alzheimer disease) neurons and astrocytes from hiPSCs were more susceptible to SARS‐CoV‐2 infection, suggesting that ApoE4 may play a causal role in COVID‐19 severity.[110] It may help us understand the potential effects of risk factors in different patient populations. Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.