Human NUP98-96 (also known as NUP98) is located near a known imprinted tumor-suppressor region in the genome (Joyce and Schofield, 1998), which could be significant as loss of heterozygosity via mutation or epigenetic modifications for the remaining NUP98-96 locus may occur in cancers exhibiting translocations. This evidence concerns the gene NUP98 and cancer.