NUP98 and neoplasm: Loss of one copy of Nup96 in the mouse leads to mildly enhanced proliferation of T-cells, supporting a potential role for Nup96 as a haplo-insufficient tumor suppressor (Chakraborty et al., 2008), but Nup96+/− mice do not appear to exhibit cell cycle deregulation in other tissues or develop cancer (Faria et al., 2006).