IRF8 and leukemia: NUP98 mutations in leukemias are associated with mutations affecting apoptosis, such as BCR-ABL, NRAS, or KRAS and ICSBP (also known as IRF8) (Gabriele et al., 1999; Gough et al., 2011; Gurevich et al., 2006; Hu et al., 2016; Slape et al., 2008).