NUP98 and cancer: Conversely, an engineered allele generating loss of one copy of Nup98 in the mouse, but with Nup96 protein expression remaining intact, cooperates with loss of the nuclear export cofactor Rae1 to increase aneuploidy (Jeganathan et al., 2005), but Nup98+/− mice have not been reported to develop cancer, nor to exhibit cell cycle de-regulation on their own (Wu et al., 2001).