MAPK8 and neoplasm: As previously described for other JNK-driven Drosophila tumor models, we observed dramatic tissue folding and invasion behaviors at both the anterior–posterior (A-P) and dorsal–ventral (D-V) compartment boundaries when Nup98-96 was inhibited in the presence of P35 expression (Fig. S3A-C) (Muzzopappa et al., 2017).