NUP98 and neoplasm: Consistent with the wing overgrowth phenotypes, several of the genes listed above have been shown to act in combination to promote tumorigenic overgrowth in flies (Toggweiler et al., 2016), and we see a striking overlap of about one-third of the genes changed upon Nup98-96 RNAi with gene expression changes observed in a well-established invasive fly tumor model (507 of 1774 genes; Table S1) (Kulshammer et al., 2015).