This article describes the role of the RAAS in the host response to COVID‐19 infection because it is the components of this system (activation of the ACE‐Ang II‐AT1R axis, suppression of the ACE2‐Ang‐(1‐7)‐MasR axis) that initiate and determine the morbidity and mortality associated with this infection. This evidence concerns the gene ACE2 and infection.