However, its major substrate is Ang II and its ability to metabolize Ang II must be considered significant in terms of limiting the actions of Ang II at the AT1R. The role of ACE2 as a receptor for SARS‐CoV, SARS‐CoV‐2, and other coronaviruses means it plays a pivotal role in the pathogenesis of these viral infections. Here, ACE2 is linked to viral infectious disease.