The study published by Lacy et al.3in 2020 analyzed the gene mutation signatures of 928 patients with DLBCL by targeted sequencing of 293 genes, and divided the patients into five clusters: MYD88, BCL2, SOCS1/SGK1, TET2/SGK1, and NOTCH2. The gene discussed is BCL2; the disease is diffuse large B-cell lymphoma.