RIPK1 is known to be involved in RIPK‐3‐MLKL‐dependent necroptosis.42, 43 Recently, activated necrosomes consisting of p‐RIPK1, p‐RIPK3 and p‐MLKL were found in granulovacuolar degeneration lesions in the degenerating neurons of preclinical AD and AD patients.23 The gene discussed is MLKL; the disease is Alzheimer disease.