Although current findings showed that RIPK1 mediated Aβ‐induced neuronal cell death in RIPK1‐MLKL‐depedent necroptosis and independent of RIPK3 activity, however, as forementioned the neuropathological hallmarks of AD include the deposition of extracellular Aβ and intracellular neurofibrillary tau proteins. Here, RIPK1 is linked to Alzheimer disease.