PTK2 and cancer: We focused on the phosphorylation status of mTOR because of its association with PC1 in the context of ADPKD and cancer, including GBM, and FAK and ERK as these proteins have been previously associated with PC1, mechanobiology and GBM.11, 17, 18, 19, 23, 24, 25, 26, 27, 28, 29, 30 T98G cells were treated with HP and/or IgPC1 for 24, 48 and 72 h.