PKD1 and brain cancer: Therefore, PC1 emerges as an additional mechanosensitive protein that participates in GBM development and progression, suggesting that it may represent a potential novel therapeutic target for this lethal brain cancer.42, 43 Further studies will provide a better understanding of the molecular underpinnings of the effects of mechano‐induced PC1 on GBM cells and will validate its role in the mechanobiology of GBM.