The response of glioma cells to increased mechanical pressure involves mechanosensitive protein molecules such as Piezo1, talin‐1, caveola‐forming proteins, tenascin‐c and Rac1.1, 2, 4, 6, 7, 38, 39 Furthermore, characterization of the nano‐mechanical properties of GBM provides a useful tool for distinguishing normal from malignant brain tissue.40 Here, RAC1 is linked to central nervous system cancer.