Antagonists of P2X7 receptors prevented ATP-induced neuronal apoptosis in glaucoma, DR, and age-related macular degeneration (AMD); the A1 receptor agonists lowered intraocular pressure in glaucoma; the A2A receptor agonists or antagonists reduced neuroinflammation in glaucoma, DR, and AMD; the A3 receptor agonists protected retinal ganglion cells (RGCs) from apoptosis in glaucoma [96]. Here, P2RX7 is linked to age-related macular degeneration.