INS and metabolic syndrome: We calculated genetic risk scores (GRSs) for T2D, as well as six partitioned genetic risk scores (pGRSs) for loci classified as involved in reduced insulin secretion with high proinsulin (IS1) and low proinsulin (IS2), insulin action (IA), adiposity (BMI), dyslipidemia (LIPID),13 and mixed features (MIX), and evaluated whether these pGRSs differed among archetypes (Figure 3A; Figure S4; Table S2).