ESR1 and cancer: Another very prominent pathway in cancer is ERK/MAPK signaling (p = 3.47 × 10−2; ESR1, FYN, ITGA3, PIK3R3, PLA2G4A, PLA2G5, RPS6KA5), which is the core of the signaling network involved in regulating cell growth, development, and division and a target of many cancer therapeutics.