PTEN and cancer: The top 15 cancer-relevant upstream regulators are (Table S3): JUN (20 target genes in the network), TNF (34), IL1B (25), TP53 (33), IL1A (13), FGF2 (15), MAP3K1 (7), EGFR (15), STAT3 (16), HRAS (16), CDH1 (7), AKT1 (11), PTEN (16), FOXO1 (13), and SMARCA4 (15).