PIK3R3 and cancer: To validate the association of these pan-cancer genes with survival, we analyzed the four top-scoring protein-coding genes (IGF2BP3, IL1RAP, PIK3R3, and CISH) in more detail by querying OncoLnc (Anaya, 2016), a tool that provides Cox regression analyses as well as Kaplan-Meier survival plots on TCGA gene expression data for different cancer types.