POMC and polycystic ovary syndrome: The current study confirmed that ACTH is an independent factor that affects the development of PCOS, which validates the hypothesis that poor hormonal control and inadequate suppression of ACTH secretion are etiological factors in the development of PCOS [25]. All serum levels of 17-OHP, and DHEA-S testosterone were higher in patients with PCOS; this indicated adrenal cause as a result of poor hormonal control.