In line with our ANN model (Table 2), the combined pharmacological action of both drugs in mRCC tumours was shown to achieve a wider coverage of the immunosurveillance evasion mechanisms than either cabozantinib or anti-PD1 compounds alone: 23% overlapping effects, and 26% and 30% compound-specific effects for cabozantinib and anti-PD1, respectively (Figure 2, Supplementary Table 3). The gene discussed is PDCD1; the disease is neoplasm.