To clarify the biological significance of the interaction between GPX4 and TAK1-TABs, phosphorylation of TAK1 T187 (autophosphorylation induces the activation of TAK1) and the downstream signaling effectors were assessed in EBV-negative and EBV-positive NPC cells after GPX4 knockdown. This evidence concerns the gene GPX4 and nasopharyngeal carcinoma.