To further confirm that the p62-Keap1-NRF2 axis is responsible for the high expression of GPX4 in EBV-infected cells, we examined the effect of NRF2 on GPX4 expression in EBV-negative and EBV-positive NPC cells using siRNAs against NRF2. Here, KEAP1 is linked to nasopharyngeal carcinoma.