GHR and obesity due to melanocortin 4 receptor deficiency: Although the expression of mGHR in liver was restored with AAV8-HLP-mGHR in Laron dwarf mice, mGHR expression is probably also required in adipose tissue to prevent obesity as studies have found that FaGHRKO (with selectively disrupted GHR in adipose tissue) mice showed an obese phenotype with increased total fat and increased adipocyte size [43, 44].