Results of this study showed that the NEK2/4/6/8 mRNA was overexpressed in LUAD patients, both in tumor stage and nodal metastasis status, and the highest expression level was mainly concentrated in phase 3/4; NEK2 mRNA was also overexpressed in LUSC patients, and the highest expression level was in phase 4; Therefore, we believe that the mRNA expression level of the above genes increases with the increase of tumor stage and nodal metastasis status. Here, NEK2 is linked to neoplasm.