Although we noticed an upregulation of select acute phase response (e.g., Saa1, Saa2, and Orm2) and fibrosis genes (e.g., Col1a1 and Timp1) in livers of IXA4-treated DIO mice (Supplementary Fig. S1p, q), IXA4 treatment did not increase liver fibrosis (Supplementary Fig. S1r) or the levels of multiple plasma cytokines (Supplementary Fig. S1s). Here, TIMP1 is linked to Hepatic fibrosis.