SAA2 and Hepatic fibrosis: Although we noticed an upregulation of select acute phase response (e.g., Saa1, Saa2, and Orm2) and fibrosis genes (e.g., Col1a1 and Timp1) in livers of IXA4-treated DIO mice (Supplementary Fig. S1p, q), IXA4 treatment did not increase liver fibrosis (Supplementary Fig. S1r) or the levels of multiple plasma cytokines (Supplementary Fig. S1s).