In mutation carriers of BRCA1 and BRCA2 (whose breast cancer risk is slightly lower and starts to increase later than that of BRCA1 carriers27) we observed AUCs of 0.61 (95% CI: 0.52–0.69) and 0.55 (95% CI: 0.46–0.64), respectively (Supplementary Fig. 3). The gene discussed is BRCA1; the disease is breast cancer.