MAD1L1 and major depressive disorder: MAD1L1 (mitotic arrest deficient 1like 1) dysfunction is associated with chromosomal instability and risk variations in this genes were linked to anxiety-related psychopathology [56], such as broad anxiety symptomatology [57] and neuroticism [58], but also further major psychiatric phenotypes, such as depression [59], bipolar disorder [60] and schizophrenia [61].