After treatment, the correlation curve of afterglow signal versus injection time showed that the relative signal intensity fluctuates raised from 100 (Fig. 6b gray line) to 120% (Fig. 6b red line) for the untreated group, while it decreased from about 100 (Fig. 6d gray line) to 60% (Fig. 6d red line) for the treated group, suggesting that the EGFR activity in the tumor region was significantly weakened. Here, EGFR is linked to neoplasm.