By performing ChIP-seq experiments in mouse lung stem cells and non-small cell lung tumours and then validating our findings in human systems, including the TCGA LUSC19 and LUAD44 datasets, lung cancer xenografts, as well as an alternative exogenous model utilising dCas9 technology53, we identified a group of enhancer-associated genes regulated by ΔNp63 in concert with p300. Here, EP300 is linked to lung carcinoma.