Histological analysis of tumours from xenografts indicated that downregulation of ∆Np63 caused a threefold decrease in proliferation, as assessed by Ki67, and a 20-fold increase in apoptosis, as assessed by cleaved caspase 3, compared to LUSC tumours expressing ∆Np63 (Fig. 1j–r). Here, CASP3 is linked to neoplasm.