Recent FISH tests (double or triple hit) demonstrated that the rearrangement of MYC (Avian Myelocytomatosis Viral Oncogene Homolog) when co-present with BCL2, BCL6, or both leads to a significantly more aggressive DLBCL, making R-CHOP ineffective [10, 11]. This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.