In this algorithm, genetic abnormalities are divided into four groups: MYD88 and CD79B mutations (MCD), BCL6 fusions and NOTCH2 mutations (BN2), NOTCH1 mutations (N1), and EZH2 mutations and BCL2 translocations (EZB); nevertheless, this algorithm can classify only 54% of DLBCL cases. This evidence concerns the gene MYD88 and diffuse large B-cell lymphoma.