It has been known that EFNA1 is a major cognate ligand of EPHA2 in vivo, but the function of EFNA1 is thought to impair EPHA2 activity in glioma cells,44–46 which promoted us to investigate the difference of PDGFA/EPHA2 axis and EFNA1/EPHA2 axis. This evidence concerns the gene EPHA2 and central nervous system cancer.