EPHA2 and glioblastoma: EPAH2 belongs to the largest RTK subfamily—EPH receptor family, and is the most frequently altered EPH members in cancers.49 In GBM, EPHA2 functions as a mitogen50 and high expression of EPHA2 is correlated with poor survival of patients.45,46 Our data clearly showed that EPHA2 was required for viability and invasiveness of GBM cells and significantly upregulated genes by EPHA2 were also involved in malignant phenotype of GBM.