EPHA2 and neoplasm: Since the involvement of EPHA2 in PDGFA signaling, we examined whether EPHA2 had roles in tumor growth and invasion of GBM cells through MTT assay an Matrigel-coated transwell assay in the context of PDGF-AA stimulation, which indicated that EPHA2 knockdown decreased viability (Supplementary Fig. S3a) and invasiveness (Supplementary Fig. S3b).