we collected a panel of potential target genes upregulated by EPHA2 and PDGFRA and found that the functions of these genes were mainly in the extracellular matrix, cell adhesion, angiogenesis, and PI3K-AKT, which were tightly correlated with malignant phenotypes of GBM with high expression of PDGFRA and EPHA2. The gene discussed is AKT1; the disease is glioblastoma.