PIK3CA and central nervous system cancer: Moreover, in KEGG pathways, top-ranked eight PDGFA-involved categories according to P-Value were EGFR tyrosine kinase inhibitor resistance, Ras signaling pathway, Pathways in cancer, Glioma, MicroRNAs in cancer, Rap1 signaling pathway, focal adhesion, and PI3K-AKT signaling pathway (Fig. 1h).