MyD88 is an essential adaptor protein for all TLRs, except TLR3106 and deletion of MyD88 in the intestines partially protects against diet-induced obesity, diabetes and inflammation and increases anti-inflammatory endocannabinoids (eCBs), restores antimicrobial peptides production and increases intestinal regulatory T cells during diet-induced obesity.107. This evidence concerns the gene MYD88 and diabetes mellitus.