Abbreviations: AC: adenocarcinoma; BMI: body mass index; ER−: estrogen receptor negative; ER+: estrogen receptor positive; FEV1: forced expiratory volume in one second; HDL: high-density lipoprotein; HMG-CoA: 3-Hydroxy-3-methylglutaryl coenzyme A; IGF-1: insulin-like growth factor 1; LDL: low-density lipoprotein; SCC: squamous cell carcinoma; SHBG: sex-hormone-binding globulin. This evidence concerns the gene ESR1 and adenocarcinoma.