A recent review on the association of telomere length and cancer risk highlighted the importance of the pleiotropic effects of certain telomere-related loci such as TERT, TERC, and OBFC1 [20], while mediation MR analyses have indicated that a considerable proportion of the association between the TERT region and lung cancer risk is mediated by telomere length [241]. The gene discussed is TERC; the disease is cancer.