Astrocytes from AD brains also expressed GFAP at greater levels than astrocytes from normal brains (t-test p value < 2.20 × 10−16) and high AD association astrocytes were significantly enriched for DAA markers (OR = 21.90, Fishers exact p value = 2.21 × 10−12, Additional file 1: Table S10). Here, GFAP is linked to Alzheimer disease.